Summary of the five PFI reports
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IN THE SPOTLIGHT MTOR Mutations in the Crosshairs of Targeted Therapy
Authors’ Affi liation: Oncology Research Unit, Pfi zer Worldwide Research and Development, San Diego, California Corresponding Author: Robert T. Abraham, Oncology Research Unit, Pfi zer Worldwide Research and Development, 10646/CB4 Science Center Drive, San Diego, CA 92121. Phone: 858-526-4772; E-mail: Robert.Abraham@ pfi zer.com doi: 10.1158/2159-8290.CD-14-0332 ©2014 American Association for ...
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SUMMARY Augmentation cheiloplasty is becoming an increasingly popular aesthetic procedure despite current methodologies having met with disappointment among surgeons and patients. The goal of this study was to examine the benefits and drawbacks of 1 device in particular-Perma Facial Implant (PFI). The senior authors (P.R. and S.W.H.) performed 832 consecutive PFI lip augmentations with excellen...
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SETD7 is associated with multiple diseases related signaling pathways. (R)-PFI-2 is the first SETD7 inhibitor with nanomolar inhibitory potency. The activity of (R)-PFI-2 is about 500 times over that of (S)-PFI-2. Understanding the mechanism behind this difference will be helpful to discovery and design of more potent SETD7 inhibitors. A computational study combining molecular dynamics simulati...
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OBJECTIVE The purpose of this study was to evaluate the relationship between body mass index (BMI) and a physical fitness index (PFI) in Chinese college freshmen based on 50-meter run. DESIGN AND METHODS Cross-sectional survey from 2007 to 2009. The records of 3825 men (age 18-31) and 4062 women (age 18-30) studying in Anhui medical university were examined. Height and weight were measured by...
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Summary writing is associated with lots of cognitive and metacognitive complexities that necessitates instruction (Hirvela & Du, 2013). Contrary to majority of studies carried out on summarization instruction, the present study addressed the underlying processes or microgenetic developments of the Iranian EFL learners’ summary writing. To this end, 41 male and female undergraduate students rece...
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